Photosensitization of Red Blood Cell Hemolysis by Lutetium Texaphyrin¶

Mehmet D. Bilgin†; M-Ali Al-Akhras‡; Mahmoud Khalili§; Hila Hemmati; Leonard I. Grossweiner

doi:10.1562/0031-8655(2000)072<0121:PORBCH>2.0.CO;2

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Mehmet D. Bilgin†,¹ M-Ali Al-Akhras‡,¹ Mahmoud Khalili§,¹ Hila Hemmati,¹ Leonard I. Grossweiner^1,*

¹Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago, IL

^**To whom correspondence should be addressed at: Wenske Laser Center, Ravenswood Hospital Medical Center, 4550 N. Winchester Avenue, Chicago, IL 60640, USA. Fax: 773-878-2649; lgflash@aol.com

Abstract

Lutetium (III) texaphyrin photosensitizes postirradiation or “delayed” photohemolysis (DPH) of human and bovine red blood cells at 730 nm by a Type-2 pathway mediated by singlet molecular oxygen. The DPH rate increases with increasing incubation temperature and with the second power of the incident fluence. The experimental DPH curves are in good agreement with a multihit kinetics model based on target theory.

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Mehmet D. Bilgin†, M-Ali Al-Akhras‡, Mahmoud Khalili§, Hila Hemmati, and Leonard I. Grossweiner "Photosensitization of Red Blood Cell Hemolysis by Lutetium Texaphyrin^¶," Photochemistry and Photobiology 72(1), 121-127, (1 July 2000). https://doi.org/10.1562/0031-8655(2000)072<0121:PORBCH>2.0.CO;2

Received: 18 January 2000; Accepted: 1 April 2000; Published: 1 July 2000

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